Pacific Standard March-April 2013 Cover

Making It Personal: Geneticist Michael Snyder Puts a Face on Personalized Medicine

personalized-medicine

Michael Snyder does not look like a man with Type 2 diabetes. Snyder, chair of the Stanford University School of Medicine’s Genetics Department, is not overweight, nor is he African American, Hispanic, or Native American—ethnic groups that are at higher risk for this chronic disease. Looking back at his family medical history, none of his relations, as far as he is aware, have been diagnosed with diabetes. His own physician, when Snyder first mentioned concerns about elevated glucose levels, told him: “There’s no way you have this. You don’t fit the profile.” It’s easy to ... Read More

Vibrating Mice Shake Up the Fight Against Diabetes

In a case of genuine good vibrations, a daily shake-up may help stave off diabetes in over-eating young people. It works in young mice, at any rate, and it works well, says Georgia Health Sciences University’s Dr. Jack C. Yu. The shaking is a 20-minute session of whole-body vibration developed by the Soviet Union’s space program to prevent muscle and bone loss during long periods of weightlessness. Its reception since has been mixed: Biomechanical stimulation has since been linked to a number of positive effects, such as improved strength and reduced bone loss, even as studies have ... Read More

Banded, Stapled, Saved

Quitting smoking, the old saw goes, is easy to do—I’ve done it dozens of times. It’s staying clean that poses the real challenge. So, too, with losing weight: despite the pills, pedometers, hypnosis, and low-cal breakfast bars, pounds have a way of creeping back onto the hips. More than a third of Americans are now overweight, and another third obese, according to the Centers for Disease Control and Prevention, with black and Hispanic women hit hardest. Among children, one in 10 pre-kindergarten students are obese; in elementary schools, that figure is one in five. Neither our bodies ... Read More

Less Intestines, Less Diabetes

By surgically removing a portion of the small intestines of a group of rats with type-1 diabetes, researchers were able to greatly lessen some of the disease’s effects. The surgery, which eliminated the upper portion of the digestive tract, activated what are called “novel sensing mechanisms” lower down, and improved the rats' ability to regulate their blood sugar. At the University of Toronto, Tony Lam and his assistant Danna Breen performed “duodenal-jejunal” bypass surgery -- taking out most of the rats’ upper intestine and part of the middle section. The jejunum is below ... Read More

High Fructose Cram Session

With final exams bearing down, college libraries are in their twice-yearly transformation to squatter camps. Students hunker down in squalid carrels, fisting Doritos, or wander vacantly through the stacks, Diet Cokes in hand. What’s a little sinful sugar to get you across the finish line? But that pint of Ben and Jerry’s could cost you. A new study from the University of California, Los Angeles suggests that an unhealthful diet of too few omega-3 fatty acids and too much high fructose corn syrup might do real damage to the brain’s ability to learn and recall information. It’s ... Read More

Turning Diabetes Treatment Upside Down

Turning Diabetes Treatment Upside Down

There is something eerily familiar about Athens, Ohio, even if you grew up in New York City. It’s the accessible beauty of Appalachia, which surrounds the town — the gentle hills, the long, flat fields, the meandering brooks and neat, smallish farms. It’s something more nefarious as well: the profound rural poverty vivid in the mini-malls and convenience stores on the outskirts of town. It’s the curse of plenty — the deal with the devil that this area made long ago with large mining corporations and fast-food chains. And it’s the number of overweight and obese people of all ages ... Read More

How the Artificial Pancreas Eases Diabetes Therapy

Turning Diabetes Treatment Upside Down

You don’t have to tell your heart to beat or your lungs to breathe. These actions are automatic. But more than 1 million Americans are stuck with a pancreas they have to operate manually. They have type 1 diabetes, meaning their pancreases don’t produce enough insulin, the hormone that regulates blood sugar. There’s no cure — only treatment in the form of regular insulin injections, which require diabetics to constantly monitor their blood sugar, or glucose, levels. Few diseases require this much attention, every day, all day. A handful of researchers in America and Europe aim to ... Read More

Pol Pot’s Legacy: Cambodian Refugees in Poor Health

Sobin weeps and curls tightly into herself, as if she's trying to disappear into the folds of her overstuffed sofa. Moments later, scowling, she plants her feet and shouts in Khmer. She shakes her fist at someone who isn't there. The objects of her fear and rage are the Khmer Rouge soldiers who forced her into slave labor as a child on what was once her family's farm. Convinced that the Khmer Rouge continue to look for her, Sobin, who lives in a small city in the Northeast, asked that her last name not be used in this article. During her captivity in the 1970s, Sobin was surviving on a ... Read More

Forgiveness, Resentment and Blood Sugar?

By now, we’ve all been alerted to the warning signs of diabetes. Frequent urination. Unquenchable thirst. Tingling in the hands and feet. And, of course, a tendency to hold a grudge. Writing in the journal Personality and Individual Differences, a research team led by University of Kentucky social psychologist C. Nathan DeWall links symptoms of Type-2 diabetes to lower levels of forgiveness. Their study suggests low levels of blood glucose are not only dangerous to your health: They may also be poisonous to your personality. DeWall and his associates describe four experiments ... Read More

Federal Food Aid Diabetes’ Best Friend?

During the health care summit last week, Sen. Tom Coburn (R-Okla.) suggested that America needs to restructure some of the systemic culture that leads to poor health in the first place, and not just invest in costly treatment of people once they're sick. In particular, he mentioned a pair of intriguing culprits. "We actually create more diabetes through the food stamp program and the school lunch program than probably any other thing," he said, precisely because we're not incentivizing people to eat well. Coburn's literal claim is hard to fact-check; there are no statistics (nor would it ... Read More