Menus Subscribe Search

‘The Pill’ for Men

• August 16, 2012 • 9:00 AM

Some 10.7 million American women take an oral contraceptive and soon, many men might, too. Researchers at the Dana-Farber Cancer Institute recently found a compound that makes male mice reversibly infertile without stunting their sex drive.

Two years ago, researchers at Dana-Farber created a hybrid molecule that was able to inhibit BRD4, a cancer-causing gene. Soon the researchers learned that the molecule, named JQ1, also inhibits another protein, BRDT, which is crucial for the development of mature sperm.

“We wondered, could the JQ1 molecule, intended initially for cancer, have activity as a male contraceptive agent?” said Dr. James Bradner, the lead author of a study in the August 17th issue of Cell.

Martin Matzuk of Baylor College of Medicine, injected mice with Bradner’s JQ1. The mice treated with the compound had lower sperm counts and less mobile sperm, rendering them infertile. Crucially, when the mice stopped receiving JQ1 their sperm count rebounded and they were able to produce healthy offspring.

“These findings suggest that a reversible, oral male contraceptive may be possible,” Bradner said in a release. “While we will be conducting more research to see if we can build on our current findings, JQ1 shows initial promise as a lead compound for male contraception.”

Female birth control pills have come with a laundry list of side effects, from nausea to decreased libido to melasma. So far JQ1 has shown no negative consequences on the animals’ testosterone levels, behavior, or future offspring. In the future, maybe it will be men checking their watches, discreetly popping a pill at the same time each day.

Matt Skenazy
Matt Skenazy, an assistant editor at Outside magazine, is a former Pacific Standard fellow. His articles have appeared in Sierra, Men’s Journal, the Surfer’s Journal, and Climbing, among others publications.

More From Matt Skenazy

A weekly roundup of the best of Pacific Standard and PSmag.com, delivered straight to your inbox.

Recent Posts

August 20 • 2:00 AM

Concluding Remarks About Housing Affordability and Supply Restricitions

Demand, not supply, plays the dominant role in explaining the housing affordability crisis. The wages are just too damn low.


August 19 • 4:00 PM

Can Lawmakers Only Make Laws That Corporations Allow?

There’s a telling detail in a recent story about efforts to close loopholes in corporate tax laws.




August 19 • 12:00 PM

How ‘Contagion’ Became Contagious

Do ideas and emotions really spread like a virus?


August 19 • 10:00 AM

Child Refugees: The New Barbarians

The disturbing rhetoric around the recent rise in child refugees into the United States from Central America may be shaping popular opinion on upcoming immigration reform.


August 19 • 8:00 AM

Making Police Departments More Diverse Isn’t Enough

Local police departments should reflect the communities they serve, but fixing that alone won’t curb unnecessary violence.


August 19 • 7:15 AM

Common Knowledge Makes Us More Cooperative

People are more inclined to take mutually beneficial risks if they know what others know.


August 19 • 6:00 AM

Seeking a Healthy Public School Lunch? Good Luck

Mystery meat will always win.


August 19 • 4:00 AM

The Positive Effects of Sports-Themed Video Games

New research finds sports-themed video games actually encourage some kids to get onto the field.


August 19 • 1:00 AM

DIY Diagnosis: How an Extreme Athlete Uncovered Her Genetic Flaw

When Kim Goodsell discovered that she had two extremely rare genetic diseases, she taught herself genetics to help find out why.



August 18 • 3:30 PM

Mister Rogers’ Heart-Healthy Neighborhood

Researchers find living in a friendly, cohesive neighborhood lowers seniors’ chances of having a heart attack.


August 18 • 2:00 PM

Wealth or Good Parenting?

Framing the privileges of the rich.


August 18 • 12:00 PM

How Much Did the Stigma of Mental Illness Harm Robin Williams?

Addiction treatment routinely fails people with mental illnesses, while mental health care often ignores addiction. And everywhere, stigma is rife. Can a tragic death prompt a more intelligent approach?


August 18 • 10:00 AM

Punished for Being Poor: The Problem With Using Big Data in the Justice System

Correctional departments use data-driven analyses because they’re easier and cheaper than individual assessments. But at what cost?


August 18 • 8:00 AM

What Americans Can Learn From a Vial of Tibetan Spit

Living high in the mountains for thousands of years, Tibetans have developed distinct biological traits that could benefit all of us, but translating medical science across cultures is always a tricky business.


August 18 • 6:00 AM

The Problems With William Deresiewicz’s New Manifesto

Excellent Sheep: a facile approach to an urgent critique.


August 18 • 4:00 AM

Ferguson Is a Serious Outlier

One black city council member is not nearly enough. In a study of city councils, only one place in America had a greater representational disparity than Ferguson, Missouri.


August 16 • 4:00 AM

Six Days in Ferguson: Voices From the Protests

A day-by-day chronology of what happened in Ferguson, drawn from the best reporting by journalists and witnesses on the ground.


August 15 • 4:00 PM

Skirting Ochobo: Big Business Finds a Way Around Local Customs

The “liberation wrapper,” which was designed to shield mouths from public view while eating, has helped a Japanese chain increase sales by over 200 percent.


August 15 • 2:00 PM

How Wall Street Tobacco Deals Left States With Billions in Toxic Debt

Politicians wanted upfront cash from a legal victory over Big Tobacco, and bankers happily obliged. The price? A handful of states promised to repay $64 billion on just $3 billion advanced.


August 15 • 12:00 PM

How the Sexes Evolved

The distinction between males and females is one of the oldest facts of biology—but how did it come to affect our social identity?



August 15 • 10:00 AM

Will Philadelphia Ever Be Home to a Middle Class?

Jake Blumgart has watched his friends decamp his adopted hometown for places with more opportunities and city services. Will anyone be left to build a better Philly?


Follow us


Common Knowledge Makes Us More Cooperative

People are more inclined to take mutually beneficial risks if they know what others know.

How a Shift in Human Head Shape Changed Everything

When did homo sapiens become a more sophisticated species? Not until our skulls underwent "feminization."

Journalists Can Get PTSD Without Leaving Their Desks

Dealing with violent content takes a heavy toll on some reporters.

Do Ticking Clocks Make Women More Anxious to Have Children?

Yes, but apparently only women who grew up poor.

Facebook App Shoppers Do What Their Friends Do

People on Facebook are more influenced by their immediate community than by popular opinion.

The Big One

One in two full-time American fast-food workers' families are enrolled in public assistance programs, at a cost of $7 billion per year. July/August 2014 fast-food-big-one
Subscribe Now

Copyright © 2014 by Pacific Standard and The Miller-McCune Center for Research, Media, and Public Policy. All Rights Reserved.