Menus Subscribe Search

Classical Music Boosts Heart Transplant Survival in Mice

• March 22, 2012 • 5:01 PM

Japanese researchers report mice who underwent heart transplants survived much longer if they were exposed to Mozart or Verdi.

Music may or may not mend a broken heart. But newly published research suggests that, at least in mice, it can reduce rejection of heart transplants.

Writing in the Journal of Cardiothoracic Surgery, a team of Japanese researchers led by Dr. Masanori Nimi describe an experiment in which a group of 8- to 12-week-old mice underwent heart transplants. The rodents were randomly assigned to one of five groups:

Those exposed to opera (a recording of Verdi’s La Traviata, conducted by Sir Georg Solti); instrumental music by Mozart; New Age music (The Best of Enya); no music; or “one of six different sound frequencies.”

After one week, the mice whose personal soundtrack featured Enya, one of the sound frequencies, or no music at all “rejected their grafts acutely,” the researchers report. Their hearts gave out 7.5 to 11 days after the transplant.

In contrast, those exposed to Verdi or Mozart “had significantly prolonged survival,” the researchers report. Median survival times were 26.5 days for those who heard Verdi and 20 days for those exposed to Mozart.

In explaining the results, the researchers point to the immune system. They report exposure to classical music generated regulatory cells, which suppress immune responses and are thus vital to preventing rejection of a transplanted organ.

“It appears possible that opera-induced regulatory cells may inhibit immune responses against allografts,” they write.

Other possible causes include “the effects on brain function produced by the specific harmony and/or other features of the music itself,” and “a decrease in postoperative stress brought about by exposure to music.”

In any event, this provides more evidence that classical music has a health-inducing impact on the body — one that was, at least for this group of mice, literally life-prolonging.

Tom Jacobs
Staff writer Tom Jacobs is a veteran journalist with more than 20 years experience at daily newspapers. He has served as a staff writer for The Los Angeles Daily News and the Santa Barbara News-Press. His work has also appeared in The Los Angeles Times, Chicago Tribune, and Ventura County Star.

More From Tom Jacobs

A weekly roundup of the best of Pacific Standard and PSmag.com, delivered straight to your inbox.

Recent Posts

August 27 • 4:00 PM

The ‘Non-Lethal’ Flash-Bang Grenades Used in Ferguson Can Actually Be Quite Lethal

A journalist says he was singed by a flash-bang fired by St. Louis County police trying to disperse a crowd, raising questions about how to use these military-style devices safely and appropriately.


August 27 • 2:00 PM

Do Better Looking People Have Better Personalities Too?

An experiment on users of the dating site OKCupid found that members judge both looks and personality by looks alone.


August 27 • 12:00 PM

Love Can Make You Stronger

A new study links oxytocin, the hormone most commonly associated with social bonding, and the one that your body produces during an orgasm, with muscle regeneration.


August 27 • 11:05 AM

Education, Interrupted

When it comes to educational access, young Syrian refugees are becoming a “lost generation.”


August 27 • 9:47 AM

No, Smartphone-Loss Anxiety Disorder Isn’t Real

But people are anxious about losing their phones, even if they don’t do much to protect them.


August 27 • 8:00 AM

A Skeptic Meets a Psychic: When You Can See Into the Future, How Do You Handle Uncertainty?

For all the crystal balls and beaded doorways, some psychics provide a useful, non-paranormal service. The best ones—they give good advice.


August 27 • 6:00 AM

Speaking Eyebrow: Your Face Is Saying More Than You Think

Our involuntary gestures take on different “accents” depending on our cultural background.


August 27 • 4:00 AM

The Politics of Anti-NIMBYism and Addressing Housing Affordability

Respected expert economists like Paul Krugman and Edward Glaeser are confusing readers with their poor grasp of demography.


August 26 • 4:00 PM

Marching in Sync May Increase Aggression

Another danger of militarizing the police: Marching in lock step doesn’t just intimidate opponents. It impacts the mindset of the marchers.


August 26 • 3:03 PM

The Best Reporting on the Federal Push to Militarize Local Police With Riot Gear, Armored Vehicles, and Assault Rifles

A few facts you might have missed about the flow of military equipment and tactics to local law enforcement.


August 26 • 2:00 PM

How the Other 23 Percent Live

Almost one-fourth of all children in the United States are now living in poverty, an increase of three million kids since 2005.


August 26 • 12:00 PM

Why Sports Need Randomness

Noah Davis talks to David Sally, one of the authors of The Numbers Game: Why Everything You Know About Soccer Is Wrong, about how uncertainty affects and enhances the games we watch.


August 26 • 10:00 AM

Honor: The Cause of—and Solution to—All of Society’s Problems

Recent research on honor culture, associated with the American South and characterized by the need to retaliate against any perceived improper conduct, goes way beyond conventional situations involving disputes and aggression.



August 26 • 8:00 AM

The Transformative Effects of Bearing Witness

How witnessing inmate executions affects those who watch, and how having an audience present can also affect capital punishment process and policy.



August 26 • 7:15 AM

Being a Couch Potato: Not So Bad After All?

For those who feel guilty about watching TV, a new study provides redemption.


August 26 • 6:00 AM

Redesigning Birth Control in the Developing World

How single-use injectable contraceptives could change family planning in Africa.


August 26 • 4:15 AM

How Gay Men Feel About Aging

Coming to terms with growing old can be difficult in the gay community. But middle-aged men are inventing new strategies to cope.


August 25 • 4:00 PM

What to Look for In Dueling Autopsies of Michael Brown

The postmortem by Michael Baden is only the beginning as teams of specialists study the body of an 18-year-old African American killed by police in Ferguson, Missouri.


August 25 • 2:00 PM

Thoughts That Can’t Be Thought and Ideas That Can’t Be Formed: The Promise of Smart Drugs

Are we asking the right questions about smart drugs? Marek Kohn looks at what they can do for us—and what they can’t.


August 25 • 12:00 PM

Does Randomness Actually Exist?

Our human minds are incapable of truly answering that question.


August 25 • 10:31 AM

Cesareans Are Still Best for Feet-First Babies

A new study confirms that surgery is the safest way to deliver a breech fetus.


August 25 • 10:00 AM

What Can Hurricanes Teach Us About Socioeconomic Mobility?

Hurricane Katrina wrought havoc on New Orleans but, nine years later, is there a silver lining to be found?


August 25 • 8:00 AM

How Low Voter Turnout Helps Public Employees

To a surprising degree, as voter turnout goes down, public employee compensation goes up.


Follow us


Subscribe Now

Education, Interrupted

When it comes to educational access, young Syrian refugees are becoming a “lost generation.”

No, Smartphone-Loss Anxiety Disorder Isn’t Real

But people are anxious about losing their phones, even if they don’t do much to protect them.

Being a Couch Potato: Not So Bad After All?

For those who feel guilty about watching TV, a new study provides redemption.

How Gay Men Feel About Aging

Coming to terms with growing old can be difficult in the gay community. But middle-aged men are inventing new strategies to cope.

Cesareans Are Still Best for Feet-First Babies

A new study confirms that surgery is the safest way to deliver a breech fetus.

The Big One

One in two full-time American fast-food workers' families are enrolled in public assistance programs, at a cost of $7 billion per year. July/August 2014 fast-food-big-one

Copyright © 2014 by Pacific Standard and The Miller-McCune Center for Research, Media, and Public Policy. All Rights Reserved.