Take heart, laboratory mice: Purdue University scientists have found that mice raised in cages can relieve stress the same way mice do in the wild. "The perception of its ability to control stress has a bigger impact on the animal than does the stress itself," said Joseph Garner, assistant professor of animal sciences, in a press release announcing the findings. "Chronic, uncontrollable stress changes animals, making them different than normal. This ultimately makes them less valid research subjects." In the study, published online in the journal Applied Animal Behavior Science, Garner ... Read More
Documentary Evidence That Nature is Weird
Today in Mice has branched out over the past year to look at the odd rodent who didn't happen to be a mouse or a rat, and today we make a clean break with rodentia and concentrate on the odd. Specifically, we refer to the solenodon, a venomous critter — we mean that literally — rediscovered in the wilds of the large Caribbean island of Hispaniola (home to Haiti and the Dominican Republic). You don't get much more endangered than to be thought possibly extinct, and both the Hispaniolan and its Cuban cousin shared that distinction until this decade. The solenodon — no fetching ... Read More
Brown Fat An Ally in Obesity Battle?
Researchers have found that mice exposed to low temperatures metabolize body fat more quickly and develop more blood vessels in their adipose tissue, where energy in the form of fat is stored. The study about the discovery, which could combat obesity and diabetes, was published in the January issue of the journal Cell Metabolism by researchers at Stockholm, Sweden's Karolinska Institutet (which awards the Nobel Prize in physiology or medicine). "This is the first time it's been shown that blood vessel growth affects the metabolic activity of adipose tissue rather than vice versa," said ... Read More
Mine Heir
Today in Mice recently sounded the alarm about calls by researchers to move beyond the mouse model of studying human disease and begin using vast databases of human health information — or larger animals like pigs and dogs — in our quest to cure the ailments that afflict us. But before anyone grows too distraught over the prospect of out-of-work rodents (or bloggers), consider this: a Belgian organization is using rats to alleviate two of Africa's greatest scourges: land mines and tuberculosis. Antwerp-based APOPO has trained African giant pouched rats to use their highly developed ... Read More
Sharing Malaria with the African Thicket Rat
Until now, the most deadly form of malaria in humans, Plasmodium falciparum, has been linked to the disease in chimpanzees, with the two similar strains thought to have diverged around the same time as humans and chimps did on the evolutionary timeline. And that's been difficult to verify, in part because the malarial form in chimpanzees and people bears such little resemblance to the disease in other animals. But a new phylogenetic analysis — based on the amplification of entire mitochondrial genomes of malarial parasites that feed on humans, rodents, birds and lizards -- suggests ... Read More
