Menus Subscribe Search

Follow us


The Straight Poop (on Fecal Transplants)

• January 17, 2013 • 10:28 AM

One of the better bits of banter I drew from Valerie Brown’s piece on bacteria for us a little over two years ago was the idea that the bacteria in our gut had a vital job to do, and like other important workers they could parachute into other locales when disaster struck:

Some researchers are even exploring the idea of stool transplants — that is, introducing a healthy person’s gut bacteria into a sick person’s intestines via the donor’s feces. Although there are not many peer-reviewed studies of this rather disturbing concept, a review in the July 2004 Journal of Clinical Gastroenterology by Australian researcher Thomas Borody found that in a large majority of the cases reported in the medical literature, fecal transplants resulted in almost immediate and long-lasting relief for people suffering from inflammatory bowel conditions and for those with chronic antibiotic-induced diarrhea. (There’s definitely a market for fecal transplants. When one scientist mentioned the success of the procedure in an interview with The Wall Street Journal, he was inundated with calls from desperate patients begging for the treatment, even though he does not practice the therapy.)

Now new work in the field of fecal transplants finds the technique may even work better for one tummy problem (recurrent infections by the bacteria Clostridium difficile) than the antibiotic usually prescribed (vancomycin) to treat the condition. The experiment by a Dutch team of researchers worked so well that it was stopped in midstream after 81 percent of those receiving a stool transplant saw their diarrhea end after the first infusion, compared to 31 percent just receiving the antibiotic. The transplant also improved the diversity of beneficial gut fauna.

A nice piece by The Los Angeles Times’ Monte Morin describes the study, and also gives some poop history:

The medicinal use of stool to treat illness dates back to 4th century China, when the physician Ge Hong described fecal solutions for the treatment of food poisoning and severe diarrhea. The remedy was considered a “medical miracle that brought patients back from the brink of death,” Dr. Faming Zhang of Nanjing Medical University wrote in the American Journal of Gastroenterology.

Later, in the 16th century Ming Dynasty, herbal healers prescribed fermented fecal solutions for abdominal ailments, calling the concoction “yellow soup” to make it more palatable.

Doctors in the West were more reticent, although it was known that certain mammals, such as dogs and camels, consumed excrement when they were ill, and that veterinarians sometimes used a fecal solution to treat ill horses. It wasn’t until 1958 that the first scientific paper on the use of fecal transplants in humans appeared in the United States.

Michael Todd
Most of Michael Todd's career has been spent in newspaper journalism, ranging from papers in the Marshall Islands to tiny California farming communities. Before joining the publishing arm of the Miller-McCune Center, he was managing editor of the national magazine Hispanic Business.

More From Michael Todd

Tags:

If you would like to comment on this post, or anything else on Pacific Standard, visit our Facebook or Google+ page, or send us a message on Twitter. You can also follow our regular updates and other stories on both LinkedIn and Tumblr.

A weekly roundup of the best of Pacific Standard and PSmag.com, delivered straight to your inbox.

Follow us


Subscribe Now

Quick Studies

Banning Chocolate Milk Was a Bad Choice

The costs of banning America's favorite kids drink from schools may outweigh the benefits, a new study suggests.

In Battle Against Climate Change, Cities Are Left All Alone

Cities must play a critical role in shifting the world to a fossil fuel-free future. So why won't anybody help them?

When a Romance Is Threatened, People Rebound With God

And when they feel God might reject them, they buddy up to their partner.

How Can We Protect Open Ocean That Does Not Yet Exist?

As global warming melts ice and ushers in a wave of commercial activity in the Arctic, scientists are thinking about how to protect environments of the future.

What Kind of Beat Makes You Want to Groove?

The science behind the rhythms that get you on the dance floor.

The Big One

One state—Pennsylvania—logs 52 percent of all sales, shipments, and receipts for the chocolate manufacturing industry. March/April 2014